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With the increasing number of cancer survivals,more attention has been paid to the cancer-related cognitive impairment (CRCI).It is urgent to explore the mechanism of CRCI as well as early intervention and relieving of such diseases.This review summarizes the application of PET in neuropsychology and cognitive impairment diseases.The advanced research progress and prospects of PET in CRCI are also introduced.
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Objective To compare treatment response according to the PERCIST1.0,RECIST1.1,EORTC,and WHO criteria in patients with colorectal liver metastases (CLM) who received neoadjuvant chemotherapy.Methods A total of 41 CLM patients (27 males,average age 68.48 years;14 females,average age 62.43 years) from January 2010 to September 2013 were included in this retrospective study.PET/CT scan was performed before chemotherapy and after 4-6 cycles′ chemotherapy.The baseline and the sequential follow-up 18F-FDG PET/CT of each patient were evaluated according to the PERCIST1.0,RECIST1.1,EORTC,and WHO criteria.The response was categorized into 4 levels including CR,PR,SD,PD.PET/CT images were used for both metabolic and anatomic evaluation.The concurrent diagnostic CT or MRI images (performed within 1 week of PET/CT) were also utilized when needed.The agreements of criteria were analyzed using Kappa test.The response rate (RR) and disease control rate (DCR) were compared using χ2 test.Results The RR and DCR according to the PERCIST1.0,EORTC and RECIST1.1 criteria were 31.71％(13/41) and 63.41％(26/41),31.71％(13/41) and 60.98％(25/41),17.07％(7/41) and 68.29％(28/41),respectively.The general comparison of PERCIST1.0 and RECIST1.1,EORTC and RECIST1.1 criteria showed good agreements (κ values: 0.711,0.689).Significant difference was not found in the DCR(χ2=2.000,P>0.05) but found in the RR(χ2=6.000,P0.05),while the RR had significant difference(χ2=6.000,P0.05) but found in the RR(χ2=8.000,P<0.05) between PERCIST1.0 and WHO criteria.Conclusions In evaluating CLM treatment response,anatomical criteria and metabolic criteria have a good consistency.But metabolic criteria are more sensitive for RR evaluating.
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[Objective] The aim of this article is to summarize the clinical experience of Dr. Shen Chunti, the successor of Menghe school in Jiangsu province ,for treating chronic cough.[Method] By following Dr. Shen, this article summarizes the academic point and clinical experience in the treatment of chronic cough, including etiology and pathogenesis, the combination of syndrome differentiation and disease differentiation ,and analyzes typical clinical cases. [Result] Dr. Shen Chunti thinks the etiology and pathogenesis of chronic cough cannot do without the wind, phlegm, Yin deficiency. The treatment should focus on dispelling wind and dispersing lung, reducing phlegm, nourishing Yin and moistening lung. And it is also important to combine the syndrome differentiation and disease differentiation .[Conclusion] Dr. Shen has accumulated rich experience in treating chronic cough ,it is worth to popularize her outstanding experience.